VE-Cadherin/CD144/CDH5 Monoclonal Antibody
Product Sizes
100 ul
£346.00
AN200252P-100UL
About this Product
- SKU:
- AN200252P
- Application:
- Western Blot
- Buffer:
- PBS
- translate.label.attr.clone:
- A1106
- Clonality:
- Monoclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- Cadherins (Calcium dependent adhesion molecules) are a class of transmembrane proteins. Cadherin-5, also known as VE-cadherin, CDH5 and CD144, an endothelial specific cell-cell adhesion molecule, plays a pivotal role in the formation, maturation and remodeling of the vascular wall. VE-Cadherin is widely considered to be specific for vascular endothelia in which it is either the sole or the predominant cadherin, often co-existing with N-cadherin. This specificity of VE-cadherin for vascular endothelial cells is important not only in blood and lymph vessel biology and medicine, but also for cell-type-based diagnoses, notably those of metastatic tumors. As a classical cadherin, VE-Cadherin links endothelial cells together by homophilic interactions mediated by its extracellular part and associates intracellularly with the actin cytoskeleton via catenins. Mechanisms that regulate VE-cadherin-mediated adhesion are important for the control of vascular permeability and leukocyte extravasation. In addition to its adhesive functions, VE-Cadherin regulates various cellular processes such as cell proliferation and apoptosis and modulates vascular endothelial growth factor receptor functions. Consequently, VE-cadherin is essential during embryonic angiogenesis.
- Host:
- Mouse
- Immunogen:
- Recombinant Rat VE-Cadherin/CD144/CDH5 protein
- Isotype:
- IgG2a
- Purification:
- Protein A Purified
- Reactivities:
- Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles., 2-8[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:cdh5_monoclonal_antibody-an200252p
