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Antibodies

Cytokeratin 8 Monoclonal Antibody

Product Sizes
100 ul
£346.00
AN200190P-100UL
About this Product
SKU:
AN200190P
Additional Names:
CYK,KRT,CYK8,KRT8,CARD2,CARD2,CK 8,CK-8,CK8,CYK8,CYKER,Cytokeratin endo A,Cytokeratin-8,DreK8,EndoA,K2C8,K2C8,K8,Keratin 8,Keratin type II cytoskeletal 8,Keratin,type II cytoskeletal 8,Keratin-8,KO,Krt 2.8,KRT8,MGC118110,MGC174782,MGC53564,MGC85764,sb:cb186,Type-II keratin Kb8,CK 8,CK8,CK-8,CYKER,Cytokeratin endo A,Cytokeratin-8,DreK8,EndoA,K2C8,Keratin,Keratin 8,Keratin type II cytoskeletal 8,Keratin-8,Krt 2.8,MGC118110,MGC174782,MGC53564,MGC85764,sb:cb186,type II cytoskeletal 8,Type-II keratin Kb8
Application:
IHC-Paraffin, Immunocytochemistry, Immunofluorescence
Buffer:
PBS
translate.label.attr.clone:
A1042
Clonality:
Monoclonal
Concentration:
1 mg/ml
Extra Details:
KRT8 (Keratin 8) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. KRT8 is the major component of the intermediate filament cytoskeleton and is predominantly expressed in simple epithelial tissues. Aberrant expression of KRT8 is associated with multiple tumor progression and metastasis.KRT8 overexpression in renal cancer cell lines promoted cell migration and invasion. In contrast, KRT8 knockdown suppressed ccRCC metastasis both in vitro and in vivo.KRT8 expression may therefore be a biomarker or potential therapeutic target to identify patients with worse survival. Diseases associated with KRT8 include Liver Cirrhosis and Cryptogenic Cirrhosis.
Host:
Mouse
Immunogen:
A synthetic peptide corresponding to the C-terminus of the Human Cytokeratin 8
Isotype:
IgG1
Purification:
Protein A Purified
Reactivities:
Human
Shipping Conditions:
Blue Ice
Storage Conditions:
-20[o]C/-70[o]C Avoid freeze/thaw cycles., 2-8[o]C Avoid freeze/thaw cycles.
Supplier:
Elabscience
Type:
Antibody: Monoclonal Antibody
Immunohistochemistry of paraffin-embedded human liver using Cytokeratin 8 Monoclonal Antibody at dilution of 1:2000.
Immunohistochemistry of paraffin-embedded human prostate using Cytokeratin 8 Monoclonal Antibody at dilution of 1:2000.
Immunohistochemistry of paraffin-embedded human colon carcinoma using Cytokeratin 8 Monoclonal Antibody at dilution of 1:2000.
Immunohistochemistry of paraffin-embedded human small intestine using Cytokeratin 8 Monoclonal Antibody at dilution of 1:2000.
Immunofluorescence analysis of KRT8 in Hela cells. Cells were fixed with 4% PFA, permeabilzed with 0.1% Triton X-100 in PBS,blocked with 10% serum, and incubated with mouse anti-Human KRT8 monoclonal antibody (dilution ratio 1:60) at 4°C overnight. Then cells were stained with the Alexa Fluor®488-conjugated Goat Anti-mouse IgG secondary antibody (green) and counterstained with DAPI (blue).Positive staining was localized to Cytoplasm.