APC Anti-Mouse CD123 Antibody[5B11]
Product Sizes
50 tests
£72.00
AN00962E-50TESTS
100 tests
£89.00
AN00962E-100TESTS
2 x 100 tests
£119.00
AN00962E-2X100TESTS
About this Product
- SKU:
- AN00962E
- Additional Names:
- IL-3 Receptor A Alpha chain,IL-3RA Alpha
- Application:
- Flow Cytometry
- Buffer:
- PBS
- translate.label.attr.clone:
- 5B11
- Clonality:
- Monoclonal
- Conjugate:
- APC
- Concentration:
- 5 ul/test
- Extra Details:
- CD123 is a 70 kD A Alpha chain subunit of the IL-3 receptor (IL-3R A Alpha). It is a member of the immunoglobulin superfamily that is expressed on hematopoietic progenitors, basophils, mast cells, and megakaryocytes. This transmembrane glycoprotein can bind IL-3 with low affinity but cannot transduce signals without association with additional protein partners. CD123 can complex with either the common B Beta chain (CDw131) or the IL-3R B Beta chain (AIC2A) to form high-affinity heterodimeric IL-3 receptors. CDw131 can complex with the A Alpha subunits of the mouse IL-3R, IL-5R and GM-CSFR to form high-affinity receptors, while the IL-3 R B Beta subunit is specific for IL-3 but binds with low affinity. IL-3 binding to the receptor complex can induce proliferation and differentiation of hematopoietic cells. The 5B11 antibody does not block binding of IL-3 to the high affinity IL-3 receptor.
- Host:
- Rat
- Immunogen:
- CD123
- Isotype:
- IgG2a
- Reactivities:
- Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2-8[o]C Do not freeze. Protect from light.
- Supplier:
- Elabscience
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:3L2gYzVK
