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Antibodies

Purified Anti-Mouse CD152 Antibody[9D9], Functional Grade

Product Sizes
100 ug
£89.00
AN008120-100UG
1 mg
£171.00
AN008120-1MG
5 mg
£490.00
AN008120-5MG
25 mg
£1515.00
AN008120-25MG
50 mg
£2247.00
AN008120-50MG
100 mg
£3211.00
AN008120-100MG
About this Product
SKU:
AN008120
Additional Names:
GRD,Cytotoxic T-lymphocyte protein,Cytotoxic T-lymphocyte-associated antigen,IDDM,CELIAC,CELIAC3,CTLA-4,Cytotoxic T-lymphocyte protein 4,Cytotoxic T-lymphocyte-associated antigen 4,GRD4,GSE,IDDM12,Cd152,Ctla4, Ly-56,Ctla4,Ly-56
Application:
Block/Inhibit/Neutralise, Depletion, Flow Cytometry
Buffer:
Sterile PBS, pH 7.2. < 1.0 EU per mg of the antibody as determined by the LAL method.
translate.label.attr.clone:
9D9
Clonality:
Monoclonal
Concentration:
>= 1 mg/ml
Extra Details:
CTLA-4 and CD28, together with their ligands B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T- and B-cell responses. CTLA-4 and CD28 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. Both CTLA-4 and CD28 are composed of a single Ig V-like extracellular domain, a transmembrane domain and an intracellular domain. CTLA-4 and CD28 are both expressed on the cell surface as disulfide-linked homodimers or as monomers. The genes encoding these two molecules are closely linked on Human chromosome 2. CTLA-4 was originally identified as a gene that was specifically expressed by cytotoxic T lymphocytes. However, CTLA-4 transcripts have since been found in both Th1 and Th2, and CD4+ and CD8+ T cell clones. Whereas, CD28 expression is constitutive on the surfaces of 95% of CD4+ T cells and 50% of CD8+ T cells and is down regulated upon T cell activation, CTLA-4 expression is upregulated rapidly following T cell activation and peaks approximately 24 hours following activation. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with 20-100-fold higher affinity than CD28. The physiological role of CTLA-4 in T cell costimulation is currently being studied. None (Azide-Free,Low Endotoxin) are perfectly suited to be used in culture or in vivo (for nonhuman studies) for functional assays blocking, neutralizing, activation or depletion where the presence of azide may damage cells or exogenous endotoxin may signal or activate cells.
Host:
Mouse
Immunogen:
Recombinant Mouse CD152 protein
Isotype:
IgG2b, kappa
Purity:
>98%
Purification:
protein a/g purified
Reactivities:
Mouse
Shipping Conditions:
Blue Ice
Storage Conditions:
2-8[o]C Avoid freeze/thaw cycles., -20[o]C Avoid freeze/thaw cycles.
Supplier:
Elabscience
Type:
Antibody: Monoclonal Antibody
HEK293T cells transfected with pcDNA3.1 plasmid encoding Mouse CD152 gene were stained with 0.2 ug Purified Anti-Mouse CD152 Antibody[9D9], Functional Grade (Right) and 0.2 ug Mouse IgG2b, K Kappa Isotype Control (Left), followed by Elab Fluor® 647-conjugated Goat Anti-Mouse IgG Secondary Antibody.
Human peripheral blood lymphocytes were stained with 0.2 ug AF/LE Purified Anti-Human CD95 Antibody[DX2] (Right) and 0.2 ug Mouse IgG1, K Kappa Isotype Control (Left), followed by Elab Fluor® 647-conjugated Goat Anti-Mouse IgG Secondary Antibody.
HEK293T cells transfected with pcDNA3.1 plasmid encoding Human IL-17A gene were stained with 0.2 ug Purified Anti-Human IL-17A Antibody[BL168] (Right) and 0.2 ug Mouse IgG1, K Kappa Isotype Control (Left), followed by Elab Fluor® 647-conjugated Goat Anti-Mouse IgG Secondary Antibody.
HEL were stained with 0.2 ug Purified Anti-Human CD90 Antibody[5E10] (Right) and 0.2 ug Mouse IgG1, K Kappa Isotype Control (Left), followed by APC-conjugated Goat Anti-Mouse IgG Secondary Antibody.
Human peripheral blood platelet were stained with 0.2 ug Purified Anti-Human CD61 Antibody[VI-PL2] (Right) and 0.2 ug Mouse IgG1, K Kappa Isotype Control (Left), followed by Elab Fluor® 647-conjugated Goat Anti-Mouse IgG Secondary Antibody.