Pentraxin 3/TSG-14 Polyclonal Antibody
Product Sizes
25 ul
£134.00
AN006880L-25UL
100 ul
£291.00
AN006880L-100UL
About this Product
- SKU:
- AN006880L
- Additional Names:
- Tsg;PTX;Tsg14;Ptx3;alpha-induced protein 5;long;pentaxin-related gene;Pentaxin-related protein PTX3;Pentraxin 3;pentraxin-3;pentraxin-related gene;pentraxin-related protein PTX3;rapidly induced by IL-1 beta;TNF alpha-induced protein 5;TNFAIP5;TSG-14;tumor necrosis factor
- Application:
- Western Blot
- Buffer:
- PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol,pH7.4
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- Pentraxin 3 (PTX3),TSG-14,was initially identified as a TNF-alpha or Il-1 beta inducible gene. It belongs to the pentraxin family,which was named originally for the homo-pentameric structure formed by its members. The pentraxin family is divided into two subfamilies: the "short" and the "long" pentraxins with approximate molecular weights of 25 kDa and 50 kDa,respectively. TSG-14 is a member of the long pentraxin subfamily,which also includes the Xenopus laevis Xl-PXN1,the guinea pig apexin/p50,the rat neuronal pentraxin I (NPI) and NPR,the human neuronal pentraxin II (NPTX2) and the human neuronal activity-related pentraxin.Mature secreted TSG-14 contains a pentaxin-like domain at its carboxy-terminus that shares 23-28% amino acid (aa) sequence similarity to C-reactive protein (CRP) and serum amyloid P component (SAP),which belongs to the short pentraxin subfamily. However,the N-terminal sequence of TSG-14 does not share aa sequence homology with any of the "short" pentaxins. Unlike CRP and SAP,which forms pentamers only,TSG-14 forms both pentameric and higher ordered oligomers. Similarly to CRP and SAP,TSG-14 binds to the complement cascade component C1q. However,TSG-14 does not bind to phosphoethanolamine,phosphocholine,or high pyruvate agarose,which are known ligands for CRP and SAP. TSG-14 is a marker of the acute phase response and is highly expressed in advanced atherosclerotic plaques. While CRP and SAP are primarily produced in the liver,TSG-14 expression is strongly up regulated by TNF-alpha,Il-1 beta,and bacterial lPS in peripheral fibroblasts,endothelial cells,and macrophages.
- Host:
- Rabbit
- Immunogen:
- Recombinant Mouse Pentraxin 3/TSG-14 protein expressed by E.coli
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:tsg_14_polyclonal_antibody-an006880l
