TNFRSF21 Polyclonal Antibody
Product Sizes
25 ul
£134.00
AN006810L-25UL
100 ul
£291.00
AN006810L-100UL
About this Product
- SKU:
- AN006810L
- Additional Names:
- UNQ,PRO,Death Receptor,Tumor Necrosis Factor Receptor Superfamily Member,TNFRSF,CD358,Death Receptor 6,Tumor Necrosis Factor Receptor Superfamily Member 21,DR6,TNFRSF21,UNQ437,PRO868, DR6,AA959878 Protein,BM 018,BM018,DR 6,DR6 Protein,MGC31965,OTTHUMP00000039915,R74815 Protein,TNFR related death receptor 6,TNFRSF 21,TNFRSF21 protein,TNR21,TR7 Protein,Tumor necrosis factor receptor superfamily member 21 precursor
- Application:
- Western Blot
- Buffer:
- PBS with 0.05% Proclin300, 1% protective protein and 50% glycerol, pH7.4
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- Death Receptor 6 (DR6), also known as TNFRSF21 and CD358, is a type I transmembrane protein in the TNF receptor superfamily. Human DR6 consists of a 308 amino acid (aa) extracellular domain (ECD) with four cysteine-rich motifs, a 21 aa transmembrane segment, and a 285 aa palmitylated cytoplasmic region that contains one death domain. Within the ECD, human and mouse DR6 share 82% aa sequence identity. DR6 is expressed as an approximately 110 kDa molecule that carries extensive N-linked and O-linked glycosylation in its extracellular region. Among hematopoietic cells, DR6 is expressed on monocytes, resting CD4+ T cells, and pro-, pre-, and naive B cells. DR6 knockout mice exhibit a Th2-biased immune response characterized by exaggerated Th2 and B cell responsiveness in combination with reduced Th1 cell responsiveness and inflammatory leukocyte infiltration. DR6 knockout mice are resistant to induced airway inflammation and experimental autoimmune encephalitis but more susceptible to severe graft versus host disease. DR6 is also expressed on developing neurons where it can bind a shed 35 kDa N-terminal fragment of APP or a fragment of APLP2. This APP fragment is generated following deprivation of neurotrophic factors, and its binding to DR6 triggers DR6-mediated axonal pruning. DR6 is constitutively expressed on some prostate cancer cells and can be induced by TNF- alpha on others.
- Host:
- Rabbit
- Immunogen:
- Recombinant Human TNFRSF21 protein expressed by Mammalian
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:p-tnfrsf21_polyclonal_antibody-an006810l
