CD74 Polyclonal Antibody
Product Sizes
25 ul
£134.00
AN006060L-25UL
100 ul
£291.00
AN006060L-100UL
About this Product
- SKU:
- AN006060L
- Additional Names:
- CD74 antigen (invariant polypeptide of major histocompatibility complex;classII antigen-associated);CD74 antigen;CD74 molecule;major histocompatibility complex;class II invariant chain;CD74;CLIP;DHLAG;DHLAGgamma chain of class II antigens;HLA class II histocompatibility antigen gamma chain;HLADG;HLA-DR antigens-associated invariant chain;HLA-DR-gamma;Ia antigen-associated invariant chain;Ia-associated invariant chain;Ia-gamma;Ii;INVG34;MHC HLA-DR gamma chain;p33
- Application:
- Immunohistochemistry
- Buffer:
- PBS
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF. Class-II-associated invariant chain peptide Binds to the peptide-binding site of MHC class II alpha/beta heterodimers forming an alpha-beta-CLIP complex, thereby preventing the loading of antigenic peptides to the MHC class II complex until its release by HLA-DM in the endosome.1 Publication Isoform p41 Stabilizes the conformation of mature CTSL by binding to its active site and serving as a chaperone to help maintain a pool of mature enzyme in endocytic compartments and extracellular space of antigen-presenting cells (APCs). Has antiviral activity by stymieing the endosomal entry of Ebola virus and coronaviruses, including SARS-CoV-2. Disrupts cathepsin-mediated Ebola virus glycoprotein processing, which prevents viral fusion and entry. This antiviral activity is specific to p41 isoform.
- Host:
- Rabbit
- Immunogen:
- Recombinant Human CD74 protein expressed by E.coli
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:p-cd74_polyclonal_antibody-an006060l
