Purified Anti-Mouse TCR V beta8.1/2 Antibody[KJ16-133.18]
Product Sizes
25 ug
£99.00
AN004820P-25UG
100 ug
£169.00
AN004820P-100UG
About this Product
- SKU:
- AN004820P
- Application:
- Flow Cytometry
- Buffer:
- Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling.
- translate.label.attr.clone:
- KJ16-133.18
- Clonality:
- Monoclonal
- Concentration:
- >= 1 mg/ml
- Extra Details:
- The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease. Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.
- Host:
- Rat
- Immunogen:
- Recombinant Mouse TCR V beta8.1/2 protein
- Isotype:
- IgG2a, kappa
- Purity:
- >98%
- Purification:
- protein a/g purified
- Reactivities:
- Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2-8[o]C Avoid freeze/thaw cycles., -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:2_antibody[kj16_133.18]-an004820p
