FITC Anti-Human CD156c(ADAM10) Antibody[11G2]
Product Sizes
20 tests
£145.00
AN00355C-20TESTS
100 tests
£291.00
AN00355C-100TESTS
2 x 100 tests
£484.00
AN00355C-2X100TESTS
About this Product
- SKU:
- AN00355C
- Additional Names:
- MADM,KUZ,alpha-secretase
- Application:
- Flow Cytometry
- Buffer:
- PBS
- translate.label.attr.clone:
- 11G2
- Clonality:
- Monoclonal
- Conjugate:
- FITC
- Concentration:
- 5 ul/test
- Extra Details:
- CD156c, also known as a disintegrin and metalloproteinase domain-containing protein 10 (ADAM10), is a 748 amino acid type I membrane glycoprotein ubiquitously expressed on most cell types. It consists of multiple functional domains, including a N-terminal prodomain, catalytic domain, cysteine-rich domain, transmembranous domain, and cytoplasmic domain. It is secreted as a precursor protein and becomes as the activate/mature form through removing the ADAM10 prodomain by proprotein convertase 7 and furin. ADAM10 functions as metalloproteinase to cleave several molecules including Notch, pro-TNF-A Alpha, amyloid precursor protein, myelin basic protein, and type IV collagen. It mediates the release of several cell adhesion molecules such as vascular endothelial cadherin or L-selectin to regulate endothelial permeability and leukocyte transmigration. Dysregulation of ADAM activity may contribute to the pathogenesis of vascular diseases.
- Host:
- Mouse
- Immunogen:
- CD156c
- Isotype:
- IgG1, kappa
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2-8[o]C Do not freeze. Protect from light.
- Supplier:
- Elabscience
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:0x1h18
