AF/LE Purified Anti-Mouse CD3e Antibody[500A2]
Product Sizes
25 ug
£66.00
AN003420-25UG
100 ug
£89.00
AN003420-100UG
1 mg
£171.00
AN003420-1MG
5 mg
£490.00
AN003420-5MG
25 mg
£1515.00
AN003420-25MG
50 mg
£2247.00
AN003420-50MG
100 mg
£3211.00
AN003420-100MG
About this Product
- SKU:
- AN003420
- Additional Names:
- T3E;T-cell surface antigen T3/Leu-4 epsilon chain;T-cell surface glycoprotein CD3 epsilon chain;Cd3e;T3; CD3epsilon
- Application:
- Flow Cytometry
- Buffer:
- Sterile PBS, pH 7.2. < 1.0 EU per mg of the antibody as determined by the LAL method.
- translate.label.attr.clone:
- 500A2
- Clonality:
- Monoclonal
- Concentration:
- >= 1 mg/ml
- Extra Details:
- Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098). In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region
- Host:
- Hamster
- Immunogen:
- CD3e|Recombinant Mouse CD3e protein
- Isotype:
- IgG
- Purity:
- >98%
- Purification:
- protein a/g purified
- Reactivities:
- Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2-8[o]C Avoid freeze/thaw cycles., -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:lHxHdS
