APC Anti-Human CD172a/b Antibody[SE5A5]
Product Sizes
20 tests
£131.00
AN00317E-20TESTS
100 tests
£249.00
AN00317E-100TESTS
2 x 100 tests
£407.00
AN00317E-2X100TESTS
About this Product
- SKU:
- AN00317E
- Additional Names:
- SIRPa,SIRPb,SIRPalpha/beta,BIT,SHPS1,MFR,P84,PTPNS1,CD172 antigen-like family member A,CD172 antigen-like family member B
- Application:
- Flow Cytometry
- Buffer:
- PBS
- translate.label.attr.clone:
- SE5A5
- Clonality:
- Monoclonal
- Conjugate:
- APC
- Concentration:
- 5 ul/test
- Extra Details:
- CD172a, also known as signal-regulatory protein A Alpha (SIRPA Alpha), src homology 2 domain-containing phosphatase substrate-1 (SHPS1), PTPNS1, BIT, MFR, and P84, is a 75-110 kD transmembrane glycoprotein involved in receptor tyrosine kinase coupled signaling pathway. It belongs to the Ig superfamily and is primarily expressed on monocytes/macrophages, granulocytes, dendritic cells, and neurons. CD172a serves as a substrate of activated receptor tyrosine kinases (RTKs). The interaction of CD172a intracellular domain with SHP-1 and SHP-2 displays negative signaling in the regulation of leukocyte adhesion and transmigration, T cell activation, macrophage fusion, and phagocytosis. CD47 (IAP) is the extracellular ligand for CD172a. SIRPA Alpha was recently demonstrated to be a specifc marker for cardiomyocytes derived from human pluripotent stem cells2.
- Host:
- Mouse
- Immunogen:
- CD172a/b
- Isotype:
- IgG1, kappa
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2-8[o]C Do not freeze. Protect from light.
- Supplier:
- Elabscience
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:RxHhi9
