Elab Fluor[R] 488-conjugated Lamin A/C Monoclonal Antibody
Product Sizes
25 ul
£106.00
AN00298L-25UL
100 ul
£189.00
AN00298L-100UL
About this Product
- SKU:
- AN00298L
- Additional Names:
- LMN1,LMNA,Lamin A/C,Prelamin-A/C
- Application:
- Immunofluorescence
- Buffer:
- PBS with 0.05% Proclin300, 1% protective protein and 50% glycerol, pH7.4
- translate.label.attr.clone:
- 4F1
- Clonality:
- Monoclonal
- Conjugate:
- Elab Fluor® 488
- Concentration:
- 1 mg/ml
- Extra Details:
- Lamin A/C is also named as LMNA,or LMN1. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis,the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability,chromatin structure and gene expression. The lack of lamin A/C can be as a novel marker for undifferentiated embryonic stem cells and lamin A/C expression is as an early indicator of differentiation (PMID: 16179429). Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy,familial partial lipodystrophy,limb girdle muscular dystrophy,dilated cardiomyopathy,Charcot-Marie-Tooth disease,and Hutchinson-Gilford progeria syndrome. This protein has 4 isoforms produced by alternative splicing with the molecular weight of 74 kDa,65 kDa,70 kDa and 64 kDa. This antibody can recognize 4 isoforms of Lamin A/C.
- Host:
- Mouse
- Immunogen:
- Recombinant human Lamin A/C protein expressed by E.coli
- Isotype:
- IgG1
- Purification:
- Protein A/G Purification
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles. Protect from light.
- Supplier:
- Elabscience
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:c_monoclonal_antibody-an00298l
