Purified Anti-PtdIns(3,4,5)P3 IgG
Product Sizes
10 ug
£372.00
ECH-Z-P345B-10UG
50 ug
£847.00
ECH-Z-P345B-50UG
250 ug
£2661.00
ECH-Z-P345B-250UG
About this Product
- SKU:
- ECH-Z-P345B
- Application:
- Detection/Quantitation, ELISA
- Clonality:
- Monoclonal
- Extra Details:
- Purified Anti-PtdIns(3,4,5)P3 monoclonal antibody. \nSubclass: IgG1 \nSource: Mouse \nApplications: ELISA, Alphascreen, Fluorescence Polarization, Protein-Lipid Overlay (PIP Strip) \n \n \n \nProduct Background: Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3,4,5-trisphosphate (PIP3), formed from PI(4,5)P2 though phosphorylation by PI 3-kinase, activates numerous signaling pathways resulting in cell proliferation, growth, survival, glucose transport and protein synthesis. High PIP3 levels from disregulation of PI3-K have been demonstrated in cancer and inflammatory diseases. PIP3 is hydrolyzed by the phosphatases PTEN to PI(4,5)P2 and SHIP to PI(3,4)P2. \nStorage \n2-8 °C for up to 30 days, -20 °C for greater than 30 days. Do not freeze thaw multiple times. \nFeatured in Publications \n1) Sweeney, G., R. R. Garg, et al. (2004). "Intracellular delivery of phosphatidylinositol (3,4,5)-trisphosphate causes incorporation of glucose transporter 4 into the plasma membrane of muscle and fat cells without increasing glucose uptake." J Biol Chem 279(31): 32233-42. \n2) Papakonstanti, E. A., A. J. Ridley, et al. (2007). "The p110delta isoform of PI 3-kinase negatively controls RhoA and PTEN." Embo J 26(13): 3050-61. \n3) Maffucci, T., C. Raimondi, et al. (2009). "A phosphoinositide 3-kinase/phospholipase Cgamma1 pathway regulates fibroblast growth factor-induced capillary tube formation." PLoS One 4(12): e8285. \n4) Wang, Y., L. M. Weiss, et al. (2010). "Coordinate control of host centrosome position, organelle distribution, and migratory response by Toxoplasma gondii via host mTORC2." J Biol Chem 285(20): 15611-8. \n \nProduct keywords: PIP3, PI(3,4,5)P3, PtdIns(3,4,5)P3, IgG, anti-PIP3 \n \n \n \nDocuments \nTechnical Data Sheet, Echelon
- Immunogen:
- Purified Anti-PtdIns(3,4,5)P3 IgG
- Isotype:
- IgG
- Purification:
- Purified
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- -20[o]C
- Supplier:
- Echelon Biosciences
- Type:
- Antibody: Monoclonal Antibody
