Purified Anti-PtdIns(4)P IgM
Product Sizes
10 ug
ECH-Z-P004-10UG
50 ug
ECH-Z-P004-50UG
250 ug
ECH-Z-P004-250UG
About this Product
- SKU:
- ECH-Z-P004
- Application:
- Detection/Quantitation, ELISA, Immunofluorescence
- Clonality:
- Monoclonal
- Extra Details:
- Purified Anti-PtdIns(4)P monoclonal antibody. \nSubclass: IgM \nSource: Mouse \nApplications: ELISA, Immunofluorescence, Fluorescence Polarization, Protein-Lipid Overlay (PIP Strip) \n \n \n \nProduct Background: Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 4-phosphate (PI(4)P) is the biosynthetic precursor to PI(4,5)P2 and has an important roles in regulating sphingomyelin and glycosphingolipid metabolism and membrane trafficking at the exit of the Golgi complex. \nStorage \n2-8 °C for up to 30 days, -20 °C for greater than 30 days. Do not freeze thaw multiple times. \nFeatured in Publications \n1) Weber, S. S., C. Ragaz, et al. (2006). "Legionella pneumophila exploits PI(4)P to anchor secreted effector proteins to the replicative vacuole." PLoS Pathog 2(5): e46. \n2) Blagoveshchenskaya, A., F. Y. Cheong, et al. (2008). "Integration of Golgi trafficking and growth factor signaling by the lipid phosphatase SAC1." J Cell Biol 180(4): 803-12. \n3) Cheong, F. Y., V. Sharma, et al. (2010). "Spatial Regulation of Golgi Phosphatidylinositol-4-Phosphate is Required for Enzyme Localization and Glycosylation Fidelity." Traffic 11(9): 1180-1190. \n4) Bojjireddy, N., J. Botyanszki, et al. "Pharmacological and Genetic Targeting of the PI4KA Enzyme Reveals Its Important Role in Maintaining Plasma Membrane Phosphatidylinositol 4-Phosphate and Phosphatidylinositol 4,5-Bisphosphate Levels." Journal of Biological Chemistry 289(9): 6120-6132. \n \nProduct keywords: PtdIns(4)P, anti-PI(4)P, PI4P, IgM \n \n \n \nDocuments \nTechnical Data Sheet, Echelon
- Immunogen:
- ptdins(4)p
- Isotype:
- IgM
- Purification:
- Purified
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- -20[o]C
- Supplier:
- Echelon Biosciences
- Type:
- Antibody: Monoclonal Antibody
