PI(4)P PolyPIPosomes
Product Sizes
100 ul
£465.00
ECH-Y-P004-100UL
250 ul
£1004.00
ECH-Y-P004-250UL
1 ml
£3548.00
ECH-Y-P004-1ML
About this Product
- SKU:
- ECH-Y-P004
- Extra Details:
- PolyPIPosomes are polymerized liposomes that show markedly increased stability (up to 6 months) vs. conventional liposomes. A biotin tag is incorporated for easy detection of PIPn-binding proteins with streptavidin reagents. \n- Uniform size (~200 nm) \n- Ready-to-use suspensions, no liposome preparation \nPolyPIPosomes have demonstrated utility in a number of assay formats: \n \n Protein pull-down \n Surface Plasmon Resonance \n Liposome overlay assay \n \n \n \n \nPI(4)P PolyPIPosomes are provided as a 1mM total lipid solution containing 5% PI(4)P. Each order of 250 uL or 1 mL of PolyPIPosomes includes 100 uL of Control PolyPIPosomes. \nFeatured in Publications \n1) Ferguson, C. G., R. D. James, et al. (2005). "Phosphoinositide-Containing Polymerized Liposomes: Stable Membrane-Mimetic Vesicles for Protein-Lipid Binding Analysis." Bioconjug Chem 16(6): 1475-1483. \n2) Elkin, S. K., D. Ivanov, et al. (2005). "A PHD finger motif in the C-terminus of RAG2 modulates recombination activity." J Biol Chem 280(31): 28701-10. \n3) Mustafa, A. K., D. B. van Rossum, et al. (2009). "Glutamatergic regulation of serine racemase via reversal of PIP2 inhibition." Proc Natl Acad Sci U S A 106(8): 2921-6. \n4) Zemskov, E. A., I. Mikhailenko, et al. (2011). "Unconventional secretion of tissue transglutaminase involves phospholipid-dependent delivery into recycling endosomes." PLoS One 6(4): e19414. \n5) Weber, S. S., C. Ragaz, et al. (2006). "Legionella pneumophila exploits PI(4)P to anchor secreted effector proteins to the replicative vacuole." PLoS Pathog 2(5): e46. \n6) Xu, Q., Y. Zhang, et al. (2016). "Phosphatidylinositol phosphate kinase PIPKI[gamma] and phosphatase INPP5E coordinate initiation of ciliogenesis." Nat Commun 7. doi:10.1038/ncomms10777 \n \nBeing bio-reactive blog: "Lipid-Ligand interaction tools: lipids are not scary intermediates anymore" \n \n \n \nDocuments \nTechnical Data Sheet, Echelon
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Echelon Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
