PI4-Kinase II alpha (PI4KIIa), active
Product Sizes
5 ug
£510.00
ECH-P21-10G-5UG
10 ug
£685.00
ECH-P21-10G-10UG
About this Product
- SKU:
- ECH-P21-10G
- Application:
- Detection/Quantitation, Western Blot
- Extra Details:
- Full-length recombinant human PI4KIIA was co-expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. Enzyme obtained from SignalChem. \n \nMolecular weight: ~79 kDa \nSequence: Full length \nSpecies: Human \nTag: GST tag \nPurity: >90 % (request TDS for lot specific information) \nSpecific Activity: >30 nmol/min/mg (request TDS for lot specific information) \nExpression System: Sf9 insect cells using baculovirus \nGenebank Number: NM_018425 \nApplications: PI 4-Kinase assay, western blot. \nFormulation: Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol. \nStorage and stability: Store product at -70C. Stable up to one year. \n \n \n \nProduct Description \n \nPI4KIIA or phosphatidylinositol 4-kinase type 2 alpha is involved in the formation of phosphatidylinositolpolyphosphates (PtdInsPs) which are centrally involved in many biologic processes ranging from cell growth and organization of the actin cytoskeleton to endo- and exocytosis. PI4KIIA phosphorylates PtdIns at the D-4 position which is an essential step in the biosynthesis of PtdInsPs. PI4KIIA is a novel regulator of tumor growth by its action on angiogenesis and HIF-1alpha regulation. PI4KIIA generates PtdIns4P-rich domains within the Golgi which regulate targeting of clathrin adaptor AP-1 complexes. PI4KIIA is also required for Wnt to regulate LRP6 phosphorylation. \n \n, Echelon
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- -70[o]C
- Supplier:
- Echelon Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Enzymes
- Manufacturer's Data Sheet:https://www.echelon-inc.com/product/pi4-kinase-ii-alpha-pi4kiia-active/
