PI(3,4,5)P3 diC16
Product Sizes
100 ug
£181.00
ECH-P-3916-100UG
500 ug
£393.00
ECH-P-3916-500UG
1 mg
£604.00
ECH-P-3916-1MG
About this Product
- SKU:
- ECH-P-3916
- Extra Details:
- PI(3,4,5)P3 diC16 (Phosphatidylinositol 3,4,5-trisphosphate diC16) is a synthetic, purified dipalmitoyl PI(3,4,5)P3. \n \nPhosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3,4,5-trisphosphate (PIP3), formed from PI(4,5)P2 though phosphorylation by PI 3-kinase, activates numerous signaling pathways resulting in cell proliferation, growth, survival, glucose transport and protein synthesis. High PIP3 levels from disregulation of PI3-K have been demonstrated in cancer and inflammatory diseases. PIP3 is hydrolyzed by the phosphatases PTEN to PI(4,5)P2 and SHIP to PI(3,4)P2. \n \n \n \nStorage \n-20 °C \nFeatured in Publications \n1) Weiner, O. D., P. O. Neilsen, et al. (2002). "A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity." Nat Cell Biol 4(7): 509-13. \n2) Merlot, S., R. Meili, et al. (2003). "A PTEN-related 5-phosphatidylinositol phosphatase localized in the Golgi." J Biol Chem 278(41): 39866-73. \n3) Shenker, B. J., M. Dlakic, et al. (2007). "A novel mode of action for a microbial-derived immunotoxin: the cytolethal distending toxin subunit B exhibits phosphatidylinositol 3,4,5-triphosphate phosphatase activity." J Immunol 178(8): 5099-108. \n4) Horikoshi, Y., S. Hamada, et al. (2011). "Phosphoinositide binding by par-3 involved in par-3 localization." Cell Struct Funct 36(1): 97-102. \n \nProduct Keywords: Dipalmitoyl Phosphatidylinositol 3,4,5-trisphosphate, PtdIns(3,4,5)P3 C16, PI(3,4,5)P3 C16, or PIP3 \n \nBulk discounts available, please email echelon@echelon-inc.com for information. \n \n \n \nDocuments \nTechnical Data Sheet, Echelon
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Echelon Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
