PI(3,5)P2 diC16
Product Sizes
100 ug
£198.00
ECH-P-3516-100UG
500 ug
£472.00
ECH-P-3516-500UG
1 mg
£752.00
ECH-P-3516-1MG
About this Product
- SKU:
- ECH-P-3516
- Extra Details:
- PI(3,5)P2 diC16 9Phosphatidylinositol 3,5-bisphosphate diC16) is a synthetic, purified dipalmitoyl PI(3,5)P2. \n \nPhosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3,5-bisphosphate is in very low abundance and is required for retrograde membrane trafficking from lysosomal and late endosomal compartments to the Golgi and is involved in autophagy. PI(3,5)P2 levels are controlled by the 5-kinase PIKfyve and the 5-phosphatase Fig4/Sac3 and disregulation is linked to several human neuropathies (eg Chacot-Marie-Tooth disease). \n \n \n \nStorage \n-20°C \nFeatured in Publications \n1. Ikonomov, O. C., D. Sbrissa, et al. (2002). "Functional dissection of lipid and protein kinase signals of PIKfyve reveals the role of PtdIns 3,5-P2 production for endomembrane integrity." J Biol Chem 277(11): 9206-11. \n2. Merlot, S., R. Meili, et al. (2003). "A PTEN-related 5-phosphatidylinositol phosphatase localized in the Golgi." J Biol Chem 278(41): 39866-73. \n3. Wollert, T., et al. (2009). "Membrane scission by the ESCRT-III complex." Nature 458(7235): 172-177. \n4. Ivarsson, Y., et al. (2013). "Prevalence, Specificity and Determinants of Lipid-Interacting PDZ Domains from an In-Cell Screen and In Vitro Binding Experiments." PLoS ONE 8(2): e54581. \n5. Narayanan, P., et al. (2018). "Myotubularin related protein-2 and its phospholipid substrate PIP2 control Piezo2-mediated mechanotransduction in peripheral sensory neurons." eLife 7: e32346. \n \nProduct Keywords: Dipalmitoyl Phosphatidylinositol 3,5-bisphosphate, PtdIns(3,5)P2 (16:0/16:0), PI(3,5)P2 C16 \n \nBulk discounts available, please email echelon@echelon-inc.com for information. \n \n \n \nDocuments \nTechnical Data Sheet, Echelon
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Echelon Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
