PI(3,4)P2 diC16
Product Sizes
100 ug
£185.00
ECH-P-3416-100UG
500 ug
£400.00
ECH-P-3416-500UG
1 mg
£614.00
ECH-P-3416-1MG
About this Product
- SKU:
- ECH-P-3416
- Extra Details:
- PI(3,4)P2 diC16 (Phosphatidylinositol 3,4-bisphosphate diC16) is a synthetic, purified dipalmitoyl PI(3,4)P2. \n \nPhosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2) is produced in stimulated cells by the action of phosphatidylinositol 3-kinases (PI3Ks) and/or lipid phosphatases (SHIP, TPTE, etc.). PI(3,4)P2 binds the pleckstrin homology (PH)-domain of AKT/PKB leading to cell survival and it also has an important role in podosome formation near focal adhesions. \n \n \n \nFeatured in Publication \n1. Dowler, S., R. A. Currie, et al. (1999). "DAPP1: a dual adaptor for phosphotyrosine and 3-phosphoinositides." Biochem J 342(Pt 1): 7-12. \n2. Karathanassis, D., R. V. Stahelin, et al. (2002). "Binding of the PX domain of p47(phox) to phosphatidylinositol 3,4- bisphosphate and phosphatidic acid is masked by an intramolecular interaction." Embo J 21(19): 5057-68. \n3. Stampoulis, P., T. Ueda, et al. (2012). "Atypical membrane-embedded PI(3,4)P2 binding site on p47phox PX domain revealed by NMR." J Biol Chem(287): 17848-17859. \n4. Ivarsson, Y., et al. (2013). "Prevalence, Specificity and Determinants of Lipid-Interacting PDZ Domains from an In-Cell Screen and In Vitro Binding Experiments." PLoS ONE 8(2): e54581. \n5. Aksnes, H., et al. (2017). "Molecular Determinants of the N-Terminal Acetyltransferase Naa60 Anchoring to the Golgi Membrane." The Journal of biological chemistry 292: 6821-6837. \n \nProduct Keywords: Dipalmitoyl Phosphatidylinositol 3,4-bisphosphate, PtdIns(3,4)P2 (16:0/16:0), PI(3,4)P2 C16, or PI34P2. \n \nBulk discounts available, please email echelon@echelon-inc.com for details. \n \n \n \nDocuments \nTechnical Data Sheet, Echelon
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Echelon Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
