PI(3,4)P2 diC8
Product Sizes
100 ug
£202.00
ECH-P-3408-100UG
500 ug
£505.00
ECH-P-3408-500UG
1 mg
£807.00
ECH-P-3408-1MG
About this Product
- SKU:
- ECH-P-3408
- Extra Details:
- PI(3,4)P2 diC8 (Phosphatidylinositol 3,4-bisphosphate diC8) is a synthetic, purified dioctanoyl PI(3,4)P2. \n \nPhosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2) is produced in stimulated cells by the action of phosphatidylinositol 3-kinases (PI3Ks) and/or lipid phosphatases (SHIP, TPTE, etc.). PI(3,4)P2 binds the pleckstrin homology (PH)-domain of AKT/PKB leading to cell survival and it also has an important role in podosome formation near focal adhesions. \n \n \n \nFeatured in Publication \n1. Elge, S., C. Brearley, et al. (2001). "An Arabidopsis inositol phospholipid kinase strongly expressed in procambial cells: synthesis of PtdIns(4,5)P2 and PtdIns(3,4,5)P3 in insect cells by 5-phosphorylation of precursors." Plant J 26(6): 561-71. \n2. Tong, Q., N. Gamper, et al. (2004). "Direct activation of the epithelial Na(+) channel by phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,4-bisphosphate produced by phosphoinositide 3-OH kinase." J Biol Chem 279(21): 22654-63. \n3. Shen, J., et al. (2009). "Deficiency of MIP/MTMR14 phosphatase induces a muscle disorder by disrupting Ca(2+) homeostasis." Nat Cell Biol 11(6): 769-776. \n4. Lopez, S. M., et al. (2013). "Determinants of the tumor suppressor INPP4B protein and lipid phosphatase activities." Biochem Biophys Res Commun 440(2): 277-282. \n5. Choi, S., et al. (2019). "A nuclear phosphoinositide kinase complex regulates p53." Nature cell biology 21: 462-475. \n \nProduct Keywords: Dioctanoyl Phosphatidylinositol 3,4-bisphosphate, PtdIns(3,4)P2 C8, PI(3,4)P2 C8, or PI34P2. \n \nBulk discounts available, please email echelon@echelon-inc.com for details. \n \n \n \nDocuments \nTechnical Data Sheet, Echelon
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Echelon Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
