D-sn-1-O-oleoyl-2-O-methylglyceryl-3-phosphothionate (2R-OMPT)
Product Sizes
500 ug
£621.00
ECH-L-9318-500UG
About this Product
- SKU:
- ECH-L-9318
- Extra Details:
- 2R-OMPT is a metabolically-stabilized analog of Lysophosphatidic Acid (LPA) which acts as potent agonist for the LPA3 receptor. Of the two enantiomers, (2S)-OMPT is more potent than (2R)-OMPT showing 5-20 fold more activity in calcium release from LPA3-transfected Sf9 and rat hepatoma Rh7777 cells. (2S)-OMPT is also more potent in inducing calcium release, IL-6 production, and MAPK and Akt phosporylation in OVCAR3 cells. \n \n \n \nStorage \n-20 °C \nFeatured in Publications \n1) Qian, L., Y. Xu, et al. (2003). "Enantioselective responses to a phosphorothioate analogue of lysophosphatidic acid with LPA3 receptor-selective agonist activity." J Med Chem 46(26): 5575-8. \n2) Altman, M. K., V. Gopal, et al. (2010). "Targeting melanoma growth and viability reveals dualistic functionality of the phosphonothionate analogue of carba cyclic phosphatidic acid." Mol Cancer 9: 140. \n \n \n \nDocuments \nTechnical Data Sheet, Echelon
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Echelon Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
