XY-14 (Lipid Phosphate Phosphatase 1 Inhibitor)
Product Sizes
500 ug
£759.00
ECH-L-9218-500UG
1 mg
£1376.00
ECH-L-9218-1MG
About this Product
- SKU:
- ECH-L-9218
- Extra Details:
- XY-14 is a competitive inhibitor of Lipid Phosphate Phosphatase 1 (LPP1) which is the major enzyme responsible for degrading lysophosphatidic acid (LPA) in platelets. XY-14 (10 uM) inhibits LPP1 in human pulmonary artery endothelial cells, preventing the dephosphorylation of sphingosine 1-phosphate (S1P) to sphingosine. \n \n \n \nStorage \n-20 °C \n \nAlternate Name: (3S)-[1,1-difluoro-3,4-bis(oleoyloxy)butyl] phosphonate \nFeatured in Publications \n1) Smyth, S. S., V. A. Sciorra, et al. (2003). "Lipid Phosphate Phosphatases Regulate Lysophosphatidic Acid Production and Signaling in Platelets." Journal of Biological Chemistry 278(44): 43214-43223. \n2) Zhao, Y., S. K. Kalari, et al. (2007). "Intracellular Generation of Sphingosine 1-Phosphate in Human Lung Endothelial Cells: Role Of Lipid Phosphate Phosphatase-1 And Sphingosine Kinase 1." J Biol Chem 282(19): 14165-77. \n \n \n \nDocuments \nTechnical Data Sheet, Echelon
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Echelon Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
