Thio-ccPA
Product Sizes
500 ug
£257.00
ECH-L-7118-500UG
1 mg
£390.00
ECH-L-7118-1MG
About this Product
- SKU:
- ECH-L-7118
- Extra Details:
- Thio-ccPA is a stabilized analogue of carbacyclic phosphatidic acid (ccPA). It inhibits the lysoPLD activity of Autotaxin (ATX) and acts as an LPA1/3 receptor antagonist. Thio-ccPA decreases the viability of B16F10, A375, and MeWo melanoma cell lines. Addition of endogenous LPA did not reverse these effects in B16F10 cells. Thio-ccPA decreased the number of pulmonary and non-pulmonary metastases in a B16F10 metastatic melanoma mouse model. \n \n \n \nStorage \n-20 °C \nFeatured in Publications \n1) Xu, Y., G. Jiang, et al. (2006). "Phosphonothioate and Fluoromethylene Phosphonate Analogues of Cyclic Phosphatidic Acid: Novel Antagonists of Lysophosphatidic Acid Receptors." Journal of Medicinal Chemistry 49(17): 5309. \n2) Altman, M. K., V. Gopal, et al. (2010). "Targeting melanoma growth and viability reveals dualistic functionality of the phosphonothionate analogue of carba cyclic phosphatidic acid." Mol Cancer 9: 140. \n \n \n \nDocuments \nTechnical Data Sheet, Echelon
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Echelon Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
