1-Hydroxy-2-methyl-2-buten-4-yl 4-diphosphate (HDMAPP)
Product Sizes
1 mg
£252.00
ECH-I-M055-1MG
10 mg
£1375.00
ECH-I-M055-10MG
About this Product
- SKU:
- ECH-I-M055
- Extra Details:
- Isoprenoid compounds are a diverse group of natural products which are essential components in all cells. Isoprenoids are biosynthesized from the simple precursors isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Eukaryotes, fungi, and some gram-positive bacteria produce IPP through the mevalonate (MVA) pathway whereas gram-negative and some gram-positive bacteria utilize the non-mevalonate or 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway. 1-Hydroxy-2-methyl-2-buten-4-yl 4-diphosphate (HDMAPP or HMBPP) is an intermediate in the non-mevalonate pathway and is biosynthesized from 2-C-Methyl-D-erythritol 2,4-cyclophosphate (cMEPP) by IspG (GcpE). It is the substrate for IspH (LytB) yielding IPP and DMAPP. In addition, HDMAPP is the most potent VG GammaVD Delta T-cell activator identified. \n \n \n \nProvided as the tris-ammonium salt \nStorage \n-20°C or below. \nFeatured in Publications \n1) deBarros, A., M. Chaves-Ferreira, et al. (2011). "CD70-CD27 interactions provide survival and proliferative signals that regulate T cell receptor-driven activation of human G GammaD Delta peripheral blood lymphocytes." European Journal of Immunology 41(1): 195. \n2) Spencer, C. T., G. Abate, et al. (2008). "Only a Subset of Phosphoantigen-Responsive G Gamma9D Delta2 T Cells Mediate Protective Tuberculosis Immunity." The Journal of Immunology 181(7): 4471-4484. \n3) Moens, E., M. Brouwer, et al. (2011). "IL-23R and TCR signaling drives the generation of neonatal VG Gamma9VD Delta2 T cells expressing high levels of cytotoxic mediators and producing IFN-gamma and IL-17." J Leukoc Biol 89(5): 743-52. \n4) Hsiao, C.-H. C. and A. J. Wiemer (2018). "A power law function describes the time- and dose-dependency of VG Gamma9VD Delta2 T cell activation by phosphoantigens." Biochem Pharmacol 158: 298-304. \n5) Rodrigues, N. V., et al. (2018). "Low-Density Lipoprotein Uptake Inhibits the Activation and Antitumor Functions of Human VG Gamma9VD Delta2 T Cells." Cancer immunology research 6(4): 448-457. \n6) Kouakanou, L., et al. (2019). "Vitamin C promotes the proliferation and effector functions of human G GammaD Delta T cells." Cellular & Molecular Immunology. DOI:10.1038/s41423-019-0247-8 \n \nBulk discounts available, please email echelon@echelon-inc.com for information. \n \n \n \nDocuments \nTechnical Data Sheet, Echelon
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Echelon Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Substrates
