Geranylgeranyl Diphosphate (GGPP)
Product Sizes
1 mg
£267.00
ECH-I-0200-1MG
10 mg
£1216.00
ECH-I-0200-10MG
About this Product
- SKU:
- ECH-I-0200
- Extra Details:
- Isoprenoid compounds are a diverse group of natural products which are essential components in all cells. Isoprenoids are biosynthesized from the simple precursors isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Eukaryotes, fungi, and some gram-positive bacteria produce IPP through the mevalonate (MVA) pathway whereas gram-negative and some gram-positive bacteria utilize the non-mevalonate or 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway. \n \n \n \nProvided as the tris-ammonium salt \nFeatured in Publications \n1. Gibot, L., J. Follet, et al. (2009). "Human caspase 7 is positively controlled by SREBP-1 and SREBP-2." Biochem J 420(3): 473-83. \n2. Lai, D., B. Lluncor, et al. (2009). "Reconstruction of the archaeal isoprenoid ether lipid biosynthesis pathway in Escherichia coli through digeranylgeranylglyceryl phosphate." Metabolic Engineering 11(3): 184. \n3. Zhou, X.-P., K.-Y. Wu, et al. (2008). "TrkB-mediated activation of geranylgeranyltransferase I promotes dendritic morphogenesis." Proceedings of the National Academy of Sciences 105(44): 17181-17186. \n4. Gruenbacher, G., H. Gander, et al. (2010). "IL-2 costimulation enables statin-mediated activation of human NK cells, preferentially through a mechanism involving CD56+ dendritic cells." Cancer Res 70(23): 9611-20. \n5. Gruenbacher, G., et al. (2016). "Ecto-ATPase CD39 Inactivates Isoprenoid-Derived VG Gamma9VD Delta2 T Cell Phosphoantigens." Cell Reports 16(2): 444-456. \n6. Sugimoto, H., et al. (2017). "Bioanalysis of farnesyl pyrophosphate in human plasma by high-performance liquid chromatography coupled to triple quadrupole tandem mass spectrometry and hybrid quadrupole Orbitrap high-resolution mass spectrometry." Anal Bioanal Chem 409(14): 3551-3560. \n \nProduct Keywords: Geranylgeranyl pyrophosphate, GGPP \n \nBulk discounts available, please email echelon@echelon-inc.com for information. \n \n \n \nDocuments \nTechnical Data Sheet, Echelon
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Echelon Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
