INPP4A, active
Product Sizes
2.5 ug
£462.00
ECH-E-8000-2.5UG
About this Product
- SKU:
- ECH-E-8000
- Extra Details:
- Human INPP4A with N-terminal 6-His tag \n \nStorage: Store product > -70 C. Enzyme is stable for at least 6 months at -70 C as undiluted stock \nSpecificity: INPP4 selectively removes the phosphate from the 4' position of the inositol ring of PtdIns(3,4)P2 \nMolecular Weight: 107 kDa \nSpecific Activity: request Certificate of Analysis (COA) \n \n \n \nProduct Description \n \nHuman INPP4A with N-terminal 6-His tag was expressed in Sf9 cells and purified using metal chelating chromatography. \n \nINPP4A is a magnesium-independent phosphatase involved in the phosphatidylinositol 3-kinase (PI3K) pathway. INPP4A and its isoenzyme INPP4B hydrolyze the 4 phosphate from the lipid second messenger phosphatidylinositol-3,4-bisphosphate (PI(3,4)P2) to form phosphatidylinositol-3-phosphate (PI(3)P). While little evidence supports its role as a tumor suppressor, INPP4A does suppress glutamate excitotoxicity in the central nervous system and is responsible for the Weeble mouse phenotype. A spontaneous frame shift mutation in the Inpp4a gene is present in the Weeble mouse resulting in selective neuronal loss in the cerebellum resulting, severe ataxia and early death. \n \nProduct Keywords: Enzyme Aliases: INPP4A; inositol polyphosphate phosphatase 4A; inositol polyphosphate 4-phosphatase type I; type I inositol-3,4-bisphosphate 4-phosphatase \n \n \n \nDocuments \n \nTechnical Data Sheet, Echelon
- Molecular Weight:
- 107 kDa
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- -70[o]C
- Supplier:
- Echelon Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Enzymes
