Sphingosine 1-Phosphate Lyase Overexpression Lysate, active
Product Sizes
250 ug
£841.00
ECH-E-5000L-250UG
About this Product
- SKU:
- ECH-E-5000L
- Extra Details:
- HEK293 cell lysate with overexpressed SPL-GFP (green fluorescent protein). \n \nStorage: >-80°C. The enzyme is stable for 6 months from the date of receipt. Avoid repeat freeze thaw cycles. \n \n \n \nProduct Description \n \nSphingsoine-1-phosphate lyase (SPL) (E.C.4.1.2.27) works as a key regulator of the final step of the sphingolipid degradative pathway by irreversibly breaking down the sphingosine-1-phosphate (S1P) to ethanolamine phosphate and hexadecenal. S1P signaling through its five receptors involves in many biological events such as proliferation, inflammation and apoptosis in cancer and other degenerative diseases. \n \nReferences \n \n1. Billich, A., et al. (2013). "Partial deficiency of sphingosine-1-phosphate lyase confers protection in experimental autoimmune encephalomyelitis." PLoS One 8(3): e59630. \n2. Engel, N., et al. (2012). "Metabolic profiling reveals sphingosine-1-phosphate kinase 2 and lyase as key targets of (phyto-) estrogen action in the breast cancer cell line MCF-7 and not in MCF-12A." PLoS One 7(10): e47833. \n3. Bedia, C., et al. (2009). "Synthesis of a fluorogenic analogue of sphingosine-1-phosphate and its use to determine sphingosine-1-phosphate lyase activity." Chembiochem 10(5): 820-2. \n4. Reiss,U., et al. (2004) "Sphingosine-phosphate Lyase Enhances Stress-induced Ceramide Generation and Apoptosis." J. Biol. Chem. 279(2): 1281-1290. \n \n \n \nDocuments \n \nTechnical Data Sheet, Echelon
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- -70[o]C
- Supplier:
- Echelon Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Lysates
