GloPIPs BODIPY TMR-PtdIns(4,5)P2, C16
Product Sizes
50 ug
£780.00
ECH-C-45M16A-50UG
100 ug
£1255.00
ECH-C-45M16A-100UG
About this Product
- SKU:
- ECH-C-45M16A
- Extra Details:
- Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 4,5-bisphosphate (PIP2) has been shown to play a central role in a variety of cellular functions. Amongst its many functions, PIP2 is a substrate for Phospholipase C-coupled G-protein pathways involved in intracellular calcium release in a number of tissues. It is also a substrate for class I phosphoinositide 3-kinase (PI3-K) forming PI(3,4,5)P3. \n \n \n \nGloPIPs are labeled at the sn-1 position with BODIPY®-FL (505/513), BODIPY®-TMR (544/574), or biotin. The sn-1 linkage in these labeled PIPs has been changed to a more stable amide from an ester. Results from experiments conducted at Echelon indicated that this minor chemical change did not have a significant effect in any of the applications tested. \nExcitation/Emission \n542/574 nm \nStorage \n-20 °C, protect from light \nFeatured in Publications \n1) Golebiewska, U., M. Nyako, et al. (2008). "Diffusion Coefficient of Fluorescent Phosphatidylinositol 4,5-bisphosphate in the Plasma Membrane of Cells." Mol Biol Cell 19(4): 1663-9. \n2) Bethoney, K. A., M. C. King, et al. (2009). "A possible effector role for the pleckstrin homology (PH) domain of dynamin." Proc Natl Acad Sci U S A 106(32): 13359-64. \n \nBulk discounts available, please email echelon@echelon-inc.com for information. \n \n \n \nDocuments \nTechnical Data Sheet, Echelon
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Echelon Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
