BODIPY FL Phosphatidylinositol 4,5-bisphosphate
Product Sizes
50 ug
£643.00
ECH-C-45F6-50UG
100 ug
£1037.00
ECH-C-45F6-100UG
About this Product
- SKU:
- ECH-C-45F6
- Extra Details:
- BODIPY FL Phosphatidylinositol 4,5-bisphosphate is a water soluble analog of PI(4,5)P2 (PIP2) labeled with the green fluorophore, Bodipy®-FL, at the sn-1 position. \n \n \n \nPhosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 4,5-bisphosphate (PIP2) has been shown to play a central role in a variety of cellular functions. Amongst its many functions, PIP2 is a substrate for Phospholipase C-coupled G-protein pathways involved in intracellular calcium release in a number of tissues. It is also a substrate for class I phosphoinositide 3-kinase (PI3-K) forming PI(3,4,5)P3. \nExcitation/Emission \n503/513 nm \nStorage \n-20 °C, protect from light \nFeatured in Publications \n1) Caromile, L. A., A. Oganesian, et al. (2010). "The neurosecretory vesicle protein phogrin functions as a phosphatidylinositol phosphatase to regulate insulin secretion." J Biol Chem 285(14): 10487-96. \n2)Rudge, S. A., D. M. Anderson, et al. (2004). "Vacuole size control: regulation of PtdIns(3,5)P2 levels by the vacuole-associated Vac14-Fig4 complex, a PtdIns(3,5)P2-specific phosphatase." Mol Biol Cell 15(1): 24-36. \n3) Oganesian, A., M. Poot, et al. (2003). "Protein tyrosine phosphatase RQ is a phosphatidylinositol phosphatase that can regulate cell survival and proliferation." Proc Natl Acad Sci U S A 100(13): 7563-8. \n4) Omar-Hmeadi, M, Gandasi, N, Barg, S (2018). "PtdIns(4,5)P2 is not required for secretory granule docking" Traffic, DOI:10.1111/tra.12562 \n \nBulk discounts available, please email echelon@echelon-inc.com for information. \n \n \n \nDocuments \nTechnical Data Sheet, Echelon
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Echelon Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
