GloPIPs Biotin-PI(4,5)P2
Product Sizes
10 ug
£288.00
ECH-C-45B6A-10UG
50 ug
£945.00
ECH-C-45B6A-50UG
About this Product
- SKU:
- ECH-C-45B6A
- Conjugate:
- Biotin
- Extra Details:
- Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 4,5-bisphosphate (PIP2) has been shown to play a central role in a variety of cellular functions. Amongst its many functions, PIP2 is a substrate for Phospholipase C-coupled G-protein pathways involved in intracellular calcium release in a number of tissues. It is also a substrate for class I phosphoinositide 3-kinase (PI3-K) forming PI(3,4,5)P3. \n \n \n \nGloPIPs are labeled at the sn-1 position with BODIPY®-FL (505/513), BODIPY®-TMR (544/574), or biotin. The sn-1 linkage in these labeled PIPs has been changed to a more stable amide from an ester. Results from experiments conducted at Echelon indicated that this minor chemical change did not have a significant effect in any of the applications tested. \nStorage \n-20°C \nFeatured in Publications \n1) Goksoy, E., Y.-Q. Ma, et al. (2008). "Structural Basis for the Autoinhibition of Talin in Regulating Integrin Activation." Molecular cell 31(1): 124. \n2) Michailidis, I., R. Rusinova, et al. (2011). "Phosphatidylinositol-4,5-bisphosphate regulates epidermal growth factor receptor activation." Pflugers Archiv European Journal of Physiology 461(3): 387-397 \n \n \n \nDocuments \nTechnical Data Sheet, Echelon
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C
- Supplier:
- Echelon Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
