IspF Inhibitor 1
Product Sizes
5 mg
£277.00
ECH-B-4102-5MG
10 mg
£447.00
ECH-B-4102-10MG
25 mg
£871.00
ECH-B-4102-25MG
About this Product
- SKU:
- ECH-B-4102
- Extra Details:
- The non-mevalonate, or MEP, pathway for isoprenoid biosynthesis is essential in gram-negative, some gram-positive bacteria, plants, and protozoa making it an attractive pathway to target for antibiotics since mammals use the mevalonate pathway to synthesize isoprenoids. IspF is the fourth step in the pathway and converts diphosphocytidyl-2-methylerythritol 2-phosphate into 2-methylerythritol 2,4-cyclodiphosphate (cMEPP). IspF inhibitor 1 (compound 3 in Geise et al.) has low micromolar activity (IC50 = 6.1-32 uM) against the recombinant enzymes and inhibits the growth of P. falciparum in a red blood cell assay. \nStorage \n4°C or below \nReference \nJ.G. Geist et al "Thiazolopyrimidine Inhibitors of 2-Methylerythritol 2,4-Cyclodiphosphate Synthase (IspF) from Mycobacteriumtuberculosis and Plasmodium falciparum" ChemMedChem 2010, 5, 1092-1101. \n \n \n \nDocuments \nTechnical Data Sheet, Echelon
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Echelon Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
