PF-8380 (Autotaxin Inhibitor)
Product Sizes
1 mg
£151.00
ECH-B-0702-1MG
10 mg
£345.00
ECH-B-0702-10MG
About this Product
- SKU:
- ECH-B-0702
- Extra Details:
- PF-8380 is a potent autotaxin (ATX) inhibitor (IC50 2.8 nM/101 nM purified enzyme/whole blood). Excessive activity of ATX is associated with numerous inflammatory conditions, cancers and other disease. Lysophosphatidic acid (LPA) produced by ATX stimulates cell proliferation through G-protein coupled receptorsLPA1-4. PF-8380 is orally bioavailable and effectively inhibits ATX in vivo reducing LPA levels in serum and at the site of inflammation in a rat arthritis model. Can delivered orally with the "Oral Formulation Vehicle". \n \n \n \nStorage \n2-8 °C \nReferences \nGierse, J. et al (2010) "A Novel Autotaxin Inhibitor Reduces Lysophosphatidic Acid Levels in Plasma and the Site of Inflammation"> Journal of Pharmacology and Experimental Therapeutics 334(1):310. \n \n \n \nDocuments \nTechnical Data Sheet, Echelon
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Echelon Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
