VO-OHpic (PTEN Inhibitor)
Product Sizes
5 mg
£200.00
ECH-B-0351-5MG
10 mg
£262.00
ECH-B-0351-10MG
25 mg
£491.00
ECH-B-0351-25MG
About this Product
- SKU:
- ECH-B-0351
- Extra Details:
- The vanadium complex VO-OHpic is a potent, reversible, allosteric inhibitor of phosphatase and tensin homologue deleted on chromosome 10 (PTEN) which hydrolyzes the 3-phosphate from phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3, formed from PI(4,5)P2 though phosphorylation by PI 3-kinase, activates numerous signaling pathways resulting in cell proliferation, growth, survival, glucose transport and protein synthesis. VO-OHpic is reported to be selective for PTEN (IC50~35 nM) compared with other cysteine-based phosphatases (PTPB Beta, SAC, MTM, & SopB, IC50>4 uM). Treatment of insulin-stimulated NIH 3T3 and L1 fibroblasts caused an increase in Akt-phosphorylation indicating inhibition of PTEN in vivo. \n \n \n \nStorage \n-20 °C \n \n \n \nDocuments \nTechnical Data Sheet, Echelon
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Echelon Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
