SF1670 (PTEN Inhibitor)
Product Sizes
1 mg
£165.00
ECH-B-0350-1MG
5 mg
£214.00
ECH-B-0350-5MG
10 mg
£327.00
ECH-B-0350-10MG
About this Product
- SKU:
- ECH-B-0350
- Extra Details:
- SF1670 is an inhibitor of PTEN (IC50 = 2 uM). PTEN (Phosphatase and Tensin Homolog deleted on Chromosome 10) is a 3' phosphoinositide phosphatase that converts PI(3,4,5)P3 to PI(4,5)P2 thus opposing PKB/Akt activation by PI 3-K. Pretreatment of neutrophils with SF1670 leads to enhanced fMLP-1 induced PI(3,4,5)P3 signaling effects such as Akt phosphorylation, NADPH oxidase-mediated superoxide formation, cell polarization, chemotactic migration, and phagocytosis. SF1670 also inhibits CD45 (IC50 = 200 nM). \n \n \n \nStorage \n2-8°C \nFeatured in Publications \n1) Cojohari, O., et al. (2016). "Human cytomegalovirus induces an atypical activation of Akt to stimulate the survival of short-lived monocytes." J Virol 90(14): 6443-6452. \n2) Yousefi, B., et al. (2017). "Balaglitazone reverses P-glycoprotein-mediated multidrug resistance via upregulation of PTEN in a PPARG Gamma-dependent manner in leukemia cells." Tumor Biology 39(10): 1010428317716501. \n3) Alsina-Sanchis, E., et al. (2018). "ALK1 (Activin-Receptor Like Kinase 1) Loss Results in Vascular Hyperplasia in Mice and Humans Through PI3K (Phosphatidylinositol 3-Kinase) Activation." Arteriosclerosis, thrombosis, and vascular biology 38(5): 1216-1229. \n4) Mitchell, J., et al. (2018). "Colonic Inhibition of Phosphatase and Tensin Homolog Increases Colitogenic Bacteria, Causing Development of Colitis in Il10-/- Mice." Inflammatory Bowel Diseases 24(8): 1718-1732. \n \n \n \nDocuments \nTechnical Data Sheet, Echelon
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Echelon Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
