K149 (SHIP2 Inhibitor)
Product Sizes
5 mg
ECH-B-0345-5MG
10 mg
ECH-B-0345-10MG
About this Product
- SKU:
- ECH-B-0345
- Extra Details:
- SH2-Domain containing inositol 5-phosphatases (SHIP1 & SHIP2) dephosphorylate the 5-position of PI(3 4 5)P3 generating PI(3 4)P2. PI(3 4)P2 activates Protein Kinase B (PKB/Akt) and promotes cell survival. SHIP2 expression and activity is increased in colorectal cancer suggesting an oncogenic role. Treatment of colorectal cancer cells with K149 (2uM) decreases PKB/Akt signaling and sensitizes the cells to 5-fluorouracil regardless of whether the cell lines have a PI3KCA mutation.References1) E. Hoekstra A.H. Das et al. aoeLipid phosphatase SHIP2 functions as oncogene in colorectal cancer by regulating PKB activationa Oncotarget 2016; 7:73525-73540. DOI: 10.18632/oncotarget.12321
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C
- Supplier:
- Echelon Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
