AS605240 (PI3-K gamma Inhibitor 1)
Product Sizes
1 mg
£120.00
ECH-B-0301-1MG
5 mg
£176.00
ECH-B-0301-5MG
About this Product
- SKU:
- ECH-B-0301
- Extra Details:
- 5-quinoxilin-6-methylene-1,3-thiazolidine-2,4-dione (AS605240) is an ATP-competitive inhibitor of PI3-KG Gamma (IC50 = 8 nM). It is selective for the G Gamma-isoform (IC50: PI 3-KA Alpha = 60 nM, PI 3-KB Beta = 270 nM, PI 3-KD Delta = 300 nM) and shows no notable activity against a wide array of protein kinases at 1 uM. In addition, AS605240 suppresses the progression of joint inflammation in a mouse model of rheumatoid arthritis and suppresses inflammation in a mouse model of lupus. \n \n \n \nSolubility \nwater: insoluble, DMSO: 2.5 mg/mL \nStorage \nstore dry between 2-8oC. Stock solutions should be stored frozen (-20oC). \nReferences \n1) M. Camps et al. "Blockade of PI3Kg suppresses joint inflammation and damage in mouse models of rheumatoid arthritis" Nature Medicine, 2005, 11, 936-943. \n2) D.F. Barber, et al., "PI3Kg inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus" Nature Medicine, 2005, 11, 933-935. \n \n \n \nDocuments \nTechnical Data Sheet, Echelon
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Echelon Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
