LY294002 (PI3-K Inhibitor)
Product Sizes
5 mg
ECH-B-0294-5MG
25 mg
ECH-B-0294-25MG
About this Product
- SKU:
- ECH-B-0294
- Extra Details:
- LY294002 (PI3-K Inhibitor) is a selective, cell permeable, potent and specific inhibitor of phosphatidylinositol 3-kinase (IC50 = 1.4 uM; purified PI 3-kinase). It does not significantly inhibit PKC, PKA, MAP kinase, S6 kinase, EGFrK, c-src kinase, PI 4-kinase, DAG kinase or rabbit kidney ATPase at concentrations of 50 uM. Induces apoptosis. In intact neutrophils stimulated with fMet-Leu-Phe, LY294002 completely abolished PI 3-kinase activity at 50 uM without cell toxicity. \n \n \n \nSpecifications \nProvided as HCl salt \nNot Sterile \nFeatured in Publications \n1. Coronas-Serna JM, Fernandez-Acero T, Molina M, Cid VJ. A humanized yeast-based toolkit for monitoring phosphatidylinositol 3-kinase activity at both single cell and population levels. Microbial Cell. 2018;5(12):545-54. \n2. Chang P, Walker MC, Williams RS. Seizure-induced reduction in PIP3 levels contributes to seizure-activity and is rescued by valproic acid. Neurobiol Dis. 2014;62:296-306. \n3. Fernandez-Acero T, Rodrguez-Escudero I, Vicente F, Monteiro MCn, Tormo JR, Cantizani J, et al. A Yeast-Based In Vivo Bioassay to Screen for Class I Phosphatidylinositol 3-Kinase Specific Inhibitors. Journal of Biomolecular Screening. 2012;17(8):1018-29. \n \n \n \nDocuments \nTechnical Data Sheet, Echelon
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Echelon Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
