FPA-124 (Akt Inhibitor)
Product Sizes
5 mg
£209.00
ECH-B-0101-5MG
About this Product
- SKU:
- ECH-B-0101
- Extra Details:
- FPA-124 is a cell-permeable inhibitor of Akt (IC50 = 100 nM), binding to the PH and kinase domains. It inhibits cell proliferation in Colo357, BxPC3, BT20, and PC3 cancer cell lines with IC50 values ranging from 7-55 nM. FPA-124 inhibited tumor growth in mice with negligible toxicity. \n \n \n \nSolubility \nDMSO: 5 mg/mL \nStorage \nStore dry between 2-8oC. Stock solutions should be stored frozen (-20oC). \nReferences \n1) V. Barve, et al. "Synthesis, Molecular Characterization, and Biological Activity of Novel Synthetic \nDerivatives of Chromen-4-one in Human Cancer Cells" J. Med. Chem., 2006, 49, 3800-3808. \n2) Biscetti, F., G. Straface, et al. (2009). "Pioglitazone enhances collateral blood flow in ischemic hindlimb of diabetic mice through an Akt-dependent VEGF-mediated mechanism, regardless of PPARgamma stimulation." Cardiovasc Diabetol 8: 49. \n3) Brito, P. M., R. l. Devillard, et al. (2009). "Resveratrol inhibits the mTOR mitogenic signaling evoked by oxidized LDL in smooth muscle cells." Atherosclerosis 205(1): 126. \n \n \n \nDocuments \nTechnical Data Sheet, Echelon
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Echelon Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
