1R,2R-B13 (Ceramidase inhibitor)
Product Sizes
5 mg
£200.00
ECH-B-0042-5MG
10 mg
£287.00
ECH-B-0042-10MG
25 mg
£504.00
ECH-B-0042-25MG
About this Product
- SKU:
- ECH-B-0042
- Extra Details:
- Ceramides are bioactive sphingolipids which induce apoptosis in cells. Ceramidases, which hydrolyze the fatty acid chain, keep ceramide levels in check and have been proposed as a target for small-molecule inhibitors for anti-cancer therapy. B13 (or D-NMAPPD) is a potent ceramidase inhibitor which causes aopotosis in a number of cell lines including colorectal, HL60, melanoma, and keratinocyes. \nStorage \n-20 °C or below. \nReferences \n1) A. Bielawska, C.M. Linardic, Y. Hannun "Ceramide-mediated biology. Determination of structural and stereospecific requirements through the use of N-acyl-phenylaminoalcohol analogs" J. Biol. Chem., 1992, 267, 18493-7. \n2) M. Raisova, G. Goltz, et al. "Bcl-2 overexpression prevents apoptosis induced by ceramidase inhibitors in malignant melanoma and HaCaT keratinocytes" FEBS Letters 2002, 516, 47-52. \n3) Bhabak, Krishna P.; Kleuser, Burkhard "Effective inhibition of acid and neutral ceramidases by novel B-13 and LCL-464 analogues" Bioorganic & Medicinal Chemistry 2013, 21, 874-882. \n \n \n \nDocuments \nTechnical Data Sheet, Echelon
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Echelon Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
