ARN14988 (aCDase Inhibitor)
Product Sizes
5 mg
£220.00
ECH-B-0041-5MG
10 mg
£316.00
ECH-B-0041-10MG
50 mg
£1021.00
ECH-B-0041-50MG
About this Product
- SKU:
- ECH-B-0041
- Extra Details:
- Acid ceramidase (aCDase) is a lysosomal amidase which hydrolyzes the acyl chain from ceramides forming sphingosine which is subsequently phosphorylated to the bioactive lipid sphingosine 1-phosphate. aCDase is upregulated in many cancer types such as melanoma, prostate, head, neck, and colon cancers. ARN14988 is a potent inhibitor of aCDase in vitro (IC50 = 12 nM) and in A375 melanoma cells (IC50 = 1.5uM). ARN14988 is weakly cytotoxic by itself, but shows a synergystic effect with some common anti-cancer drugs (5-Fluorouracil, vemurafinib, and taxol) in proliferative G361 cells. \nStorage \n-20 °C or below \nReferences \n N. Realini, et al. "Acid Ceramidase in Melanoma: expression, localization, and effects of pharmacological inhibition" J. Biol. Chem., 2016, 291, 2422-2434. \n \n \n \nDocuments \nTechnical Data Sheet, Echelon
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Echelon Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
