2-Acetyl-5-tetrahydroxybutyl imidazole (THI)
Product Sizes
1 mg
£267.00
ECH-B-0031-1MG
5 mg
£886.00
ECH-B-0031-5MG
10 mg
£1543.00
ECH-B-0031-10MG
About this Product
- SKU:
- ECH-B-0031
- Extra Details:
- THI is a trace component present in the industrially produced food colorant caramel color III. It acts as an immunosuppressant by inhibiting the enzyme sphingosine 1-phosphate lyase (S1PL) which fragments S1P to hexadecenal and phosphoethanolamine. Administration of THI in drinking water to mice (50 ug/mL) resulted in decreased S1PL activity, increased S1P levels in lymphoid tissues and reduced egress of CD4+ and CD8+ T cells (lymphopenia). \n \n \n \nReferences \n1) J. T. Bagdanoff, et al. "Inhibition of Sphingosine-1-phosphate Lyase for the Treatment of Autoimmune Disorders." J. Med. Chem. 2009, 52, 3941-3953. \n2) G.F. Houben, et al. "Effects of Ammonia Caramel and Tetrahydroxybutylimidazole on the Immune System of Rats." Arch. Toxicol., 1989, 13, 183-187. \n3) S.R. Schwab, et al. "Lymphocyte Sequestration Through S1P Lyase Inhibition and Disruption of S1P Gradients." Science 2005, 309, 1735-1739. \nStorage \n-20°C \n \n \n \nDocuments \nTechnical Data Sheet, Echelon
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Echelon Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
