SKI-178 (SPHK1 Inhibitor)
Product Sizes
10 mg
£239.00
ECH-B-0028-10MG
25 mg
£448.00
ECH-B-0028-25MG
About this Product
- SKU:
- ECH-B-0028
- Extra Details:
- SKI-178 is a selective inhibitor of sphingosine kinase 1 which is active in vitro and in vivo. SKI-178 is a competitive inhibitor of sphingosine binding to SPHK1 (Ki = 1.3 uM) and shows no inhibition of SPHK2 up to 25 uM. SKI-178 is cytotoxic to numerous cancer cell lines (MCF-7, A549, Panc-1, etc) at low to sub-micromolar concentrations. \nStorage \n-20 °C \nReferences \n1) J.A. Hengst et al. "Development of a sphingosine kinase 1 specific small-molecule inhibitor" Bioorg. Med. Chem. Lett. 2010, 20, 7498-7502. doi: 10.1016/j.bmcl.2010.10.005 \n2) T.E. Dick et al. "The apoptotic mechanism of action of the sphingosine kinase 1 selective inhibitor SKI-178 in human acute myeloid leukemia cell lines" J. Pharmacol. Exp. Ther. 2015, 352, 494-508. doi: 10.1124/jpet.114.219659 \n \n \n \nDocuments \nTechnical Data Sheet, Echelon
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Echelon Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
