DES1 Inhibitor
Product Sizes
10 mg
£220.00
ECH-B-0027-10MG
50 mg
£640.00
ECH-B-0027-50MG
About this Product
- SKU:
- ECH-B-0027
- Extra Details:
- SKI-II is a commonly used inhibitor of both sphingosine kinase I (SPHK1) and 2 (SPHK2). Recently it has been shown to inhibit dihydroceramide desaturase (Des1) which Aurelio et al. suggest is actually responsible for its anti-proliferative activity, not SPHK inhibition. Compound 34 is an analog of SKI-II and is a selective Des1 inhibitor which shows no activity against either SPHK1 or SPHK2. 34 inhibits PC3 cell growth (GIC50 = 0.34 uM) but some of this may be due to inhibition of another target \nReferences \nL. Aurelio, C.V. Scullino, et al.. "From Sphingosine Kinase to Dihydroceramide desaturase: A Structure?Activity Relationship (SAR) Study of the Enzyme Inhibitory and Anticancer Activity of 4-((4-(4-Chlorophenyl)thiazol-2-yl)amino)phenol (SKI-II)" J. Med. Chem., 59, 965-984, DOI: 10.1021/acs.jmedchem.5b01439. \n \n \n \nDocuments \nTechnical Data Sheet, Echelon
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Echelon Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
