ABC294640 (SPHK2 Inhibitor)
Product Sizes
5 mg
£213.00
ECH-B-0025-5MG
25 mg
£520.00
ECH-B-0025-25MG
100 mg
£1231.00
ECH-B-0025-100MG
About this Product
- SKU:
- ECH-B-0025
- Extra Details:
- ABC294640 is an orally bioavailable, selective inhibitor of sphingosine kinase 2 (SPHK2 or SK2). Sphingosine kinases phosphorylate sphingosin producing the bioactive lipid sphingosine 1-phosphate which has roles in cell proliferation and cell motility. Sphingosine kinases are upregulated in numerous forms of cancer and ABC294640, alone or in combination, has been shown to suppress growth in kidney, breast, liver, colon, and lung cancer cell lines. \nStorage \n-20°C or below \nReferences \n1) M. B. Thomas, et al. "Phase I trial of ABC294640, a first-in-class sphingosine kinase-2 inhibitor" Mol. Cancer. Ther. 2013, 12, C62, DOI: 10.1158/1535-7163.TARG-13-C62. \n2) K.J French, et al. "Pharmacology and antitumor activity of ABC294640, a selective inhibitor of sphingosine kinase-2." J. Pharmacol. Exp. Ther. 2010, 333, 129-139. \n3) M.M. Gestaut, et al. "Inhibition of sphingosine kinase-2 ablates androgen resistant prostate cancer proliferation and survival." Pharmacol. Rep. 2014, 66, 174-178. \n \n \n \nDocuments \nTechnical Data Sheet, Echelon
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Echelon Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
