Pancreatic Leukocyte Elastase Substrate, colorimetric
Product Sizes
5 mg
£261.00
ECH-881-15-5MG
About this Product
- SKU:
- ECH-881-15
- CAS Number:
- 70967-90-7
- Extra Details:
- CAS Number: 70967-90-7 \nMolecular Weight: 590.27 \nSalt Form: N/A \nPurity: >96% \nSequence (3-letter): MeOSuc-Ala-Ala-Pro-Val-pNA \nSequence (1-letter): MeOSuc-AAPV-pNA \nStorage: -20 ?C or below \nSolubility: DMSO (20 mM), methanol (1 mg/ml), DMF, and ethanol \n \nPancreatic Leukocyte Elastase Substrate (MeOSuc-AAPV-pNA), aka Elastase Substrate 1, is a highly sensitive colorimetric substrate for pancreatic leukocyte elastase (neutrophil elastase). Pancreatic leukocyte elastase is a serine proteinase that is secreted by neutrophils during inflammation to destroy bacteria as well as host tissue. MeOSuc-AAPV-pNA can be used for in vitro assays with purified enzyme or with biological fluids or conditioned medium. Reaction progress is detected by monitoring substrate hydrolysis at 405-410 nm. \nThis product is not a substrate for cathepsin G or chymotrypsin. \nReferences \n1. A.M. et al. (2002) ?Dipeptidyl peptidase I activates neutrophil-derived serine proteases and regulates the development of acute experimental arthritis? J. Clin. Invest. 109 (3): 363?371. \n2. Lonky, S. A and Whole, H. (1983) ?Regulation of elastolysis of insoluble elastin by human leukocyte elastase: stimulation by lysine rich lugans, anionic detergents and ionic strength? Biochemistry 22: 3714. \n3. Stein, R. L., Viscarello, B. R., and Vildonger, R. A. (1984) ?Catalysis by human leukocyte elastase. II. Rate limiting deacylation for specific p-nitroanilides and amides? J. Am. Chem. Soc.. 106: 796., Echelon
- Format:
- Colorimetric
- Molecular Weight:
- 590.27
- Sequence:
- MeOSuc-Ala-Ala-Pro-Val-pNA \n
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C
- Supplier:
- Echelon Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Manufacturer's Data Sheet:https://www.echelon-inc.com/product/meosuc-ala-ala-pro-val-pna-pancreatic-leukocyte-elastase-substrate-colorimetric/
