Caspase 8 Substrate, colorimetric

Product Sizes

5 mg

£219.00

ECH-860-56-5MG

25 mg

£598.00

ECH-860-56-25MG

About this Product

SKU:: ECH-860-56
CAS Number:: 219138-21-3
Extra Details:: CAS Number: 219138-21-3 \nMolecular Weight: 638.26 \nSalt Form: N/A \nPurity: >96% \nSequence (3-letter): Ac-Ile-Glu-Thr-Asp-pNA \nSequence (1-letter): Ac-IETD-pNA \nStorage: -20 ?C or below \nSolubility: DMSO \n \nAc-IETD-pNA is a substrate for caspase-8 and granzyme B. Caspases are a family of cysteine proteases that have important intracellular roles in inflammation and apoptosis. Caspase-8 is an attractive therapeutic target for a variety of degenerative disorders. The absorbance maximum for the cleaved pNA is at 405 nm. \nReferences \n1. N.A.Thornberry et al., (1997) ?A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis? J. Biol. Chem. 272: 17907. \n2. Watt, W. et al. (1999) ?The atomic-resolution structure of human caspase-8, a key activator of apoptosis? Structure 7 (9): 1135?1143., Echelon
Molecular Weight:: 638.26
Sequence:: Ac-Ile-Glu-Thr-Asp-pNA \n
Shipping Conditions:: Ambient
Storage Conditions:: -20[o]C
Supplier:: Echelon Biosciences
Type:: Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides

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