Caspase 6 (Mch2) Substrate, fluorogenic

Product Sizes

5 mg

£275.00

ECH-860-52-5MG

25 mg

£816.00

ECH-860-52-25MG

About this Product

SKU:: ECH-860-52
CAS Number:: 219137-97-0
Extra Details:: CAS Number: 219137-97-0 \nMolecular Weight: 673.3 \nSalt Form: N/A \nPurity: >96% \nSequence (3-letter): Ac-Val-Glu-Ile-Asp-AMC \nSequence (1-letter): Ac-VEID-AMC \nStorage: -20 ?C or below \nSolubility: DMSO, phosphate buffer pH 7.5 \n \nAc-VEID-AMC is a fluorogenic substrate for caspase 6 (Mch-2?), a member of the cysteine-aspartate protease family, which play a central role in the execution-phase of apoptosis. The excitation/emission maximum of AMC is 340-360/440-460 nm, respectively. Ac-VEID-AMC is based on lamin A site of cleavage. \nReferences \n1. Benford, H.L. et al. (2001) ?Visualization of bisphosphonate-induced caspase-3 activity in apoptotic osteoclasts in vitro? 28 (5): 465?473. \n2. Rouaux, C. e al. (2003) ?Critical loss of CBP/p300 histone acetylase activity by caspase-6 during neurodegeneration? EMBO J. 22 (24): 6537?6549., Echelon
Molecular Weight:: 673.3
Sequence:: Ac-Val-Glu-Ile-Asp-AMC \n
Shipping Conditions:: Ambient
Storage Conditions:: -20[o]C
Supplier:: Echelon Biosciences
Type:: Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides

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