Ac-Val-Asp-Val-Ala-Asp-pNA (Caspase 2 (ICH-1) Substrate)

Product Sizes

5 mg

£241.00

ECH-860-46-5MG

25 mg

£686.00

ECH-860-46-25MG

About this Product

SKU:: ECH-860-46
CAS Number:: 189684-53-5
Extra Details:: CAS Number: 189684-53-5 \nMolecular Weight: 679.28 \nSalt Form: N/A \nPurity: >96% \nSequence (3-letter): Ac-Val-Asp-Val-Ala-Asp-pNA \nSequence (1-letter): Ac-VDVAD-pNA \nStorage: -20 ?C or below \n \nAc-Val-Asp-Val-Ala-Asp-pNA is a chromogenic substrate for Caspase 2. Caspase 2, part of the ICH-1 sub-family, is a cysteine protease with a poorly defined role in apoptosis. It associates with several apoptotic proteins such as death effector filament-forming Ced-4-like apoptosis protein (DEFCAP), RIP-associated Ich-1/Ced-3-homologue protein with a death domain (RAIDD), and apoptosis repressor with caspase recruitment domain (ARC). Caspase 2 can be activated by the PIDDosome formed by the association of PIDD1 and CRADD. Recent work demonstrates that Caspase-2 resides in the mitochondria and is essential for stress-induced apoptosis. Caspase-2 cleaves at an Asp residue with a preferred sequence of Val-Asp-Val-Ala-Asp-X. \n \nActivity is quantified by the release of p-nitroaniline which is measured by absorbance at 405 nm., Echelon
Molecular Weight:: 679.28
Sequence:: Ac-Val-Asp-Val-Ala-Asp-pNA \n
Shipping Conditions:: Ambient
Storage Conditions:: -20[o]C
Supplier:: Echelon Biosciences
Type:: Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides

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