Caspase 1 (ICE) Substrate

Product Sizes

5 mg

£275.00

ECH-860-41-5MG

25 mg

£816.00

ECH-860-41-25MG

About this Product

SKU:: ECH-860-41
Extra Details:: Molecular Weight: 723.28 \nSalt Form: N/A \nPurity: >96% \nSequence (3-letter): Ac-Tyr-Glu-Val-Asp-AMC \nSequence (1-letter): Ac-YEVD-AMC \nStorage: -20 ?C or below \n \nAc-Tyr-Glu-Val-Asp-AMC is a fluorogenic substrate for Caspase 1. Caspase 1/Interleukin 1b converting enzyme (ICE) is a cysteine protease that cleaves specifically at aspartic acid. ICE converts inactive IL-1 beta precursor to a pro-inflammatory cytokine that mediates a wide range of immune and inflammatory response. ICE-related cysteine proteases are required for E1A-induced, p53-dependent apoptosis in baby rat kidney (BRK) cells. Adenovirus E1B 19K protein, which is a potent inhibitor of apoptosis, inhibits activation of these proteases in BRK cells. \n \nActivity is quantified by release of free fluorescent 7-amino-4-methylcoumarin (AMC) which excites at 360-380 nm and emits at 440-460 nm., Echelon
Molecular Weight:: 723.28
Sequence:: Ac-Tyr-Glu-Val-Asp-AMC \n
Shipping Conditions:: Ambient
Storage Conditions:: -20[o]C
Supplier:: Echelon Biosciences
Type:: Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides

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