Caspase 3 Substrate, fluorogenic
Product Sizes
5 mg
£316.00
ECH-860-30-5MG
About this Product
- SKU:
- ECH-860-30
- Extra Details:
- Molecular Weight: 760 \nSalt Form: N/A \nPurity: >95% \nSequence (3-letter): Ac-Asp-Met-Gln-Asp-AFC \nSequence (1-letter): Ac-DMQD-AFC \nStorage: -20 ?C or below \n \nAc-Asp-Met-Gln-Asp-AFC is a fluorogenic substrate for Caspase 3 (Apopain). Caspase 3 is a cysteine protease that is rapidly activated during apoptosis and that cleaves several substrates, including poly(ADP-ribose) polymerase (PARP). Caspase 3 is activated by Caspases 8, 9 and 10 and cleaves and activates caspase 6 and 7. Caspase 3 cleaves the amyloid precursor protein (APP) contributing to Amyloid beta formation and has been implicated in Alzheimer?s disease and proposed as a target for drug discovery. \n \nActivity is quantified by release of free fluorescent 7-amino-4-trifluoromethylcoumarin (AFC) which excites at 395-400 nm and emits at 495-505 nm. \nReferences \n1. Talanian, R.V. et al. (1997) ?Substrate Specificities of Caspase Family Proteases? J. Biol. Chem. 272 (15): 9677?9682. \n2.Nagane, M. et al. (1998) ?Drug resistance of human glioblastoma cells conferred by a tumor-specific mutant epidermal growth factor receptor through modulation of Bcl-XL and caspase-3-like proteases? Proc. Natl. Acad. Sci. USA 95 (10): 5724?5729. \n3) Troy T. Rohn, Elizabeth Head ?Caspases as Therapeutic Targets in Alzheimer?s Disease: Is It Time to ?Cut? to the Chase?? Int J Clin Exp Pathol. 2009; 2(2): 108?118., Echelon
- Molecular Weight:
- 760
- Sequence:
- Ac-Asp-Met-Gln-Asp-AFC \n
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C
- Supplier:
- Echelon Biosciences
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Manufacturer's Data Sheet:https://www.echelon-inc.com/product/ac-asp-met-gln-asp-afc-caspase-3-substrate-fluorogenic/
